Delaware Route 141 (DE 141) is a state highway that serves as a western bypass of Wilmington, Delaware. Its southern terminus is at DE 9 and DE 273 in New Castle and its northern terminus is an interchange with U.S. Route 202 (US 202) and DE 261 near Fairfax. The route heads north from DE 9 and DE 273 on four-lane divided Basin Road, becoming concurrent with US 202 at an interchange with US 13/US 40 in Wilmington Manor, and passes to the east of Wilmington Airport. The highway becomes a freeway and reaches an interchange with Interstate 95 (I-95) and I-295, at which point US 202 splits from DE 141. The DE 141 freeway continues north through Newport to Prices Corner. Here, the freeway segment ends and DE 141 continues northeast as a surface road, with another brief freeway segment in Greenville. The route heads east across the Brandywine Creek on the Tyler-McConnell Bridge and continues to US 202 and DE 261.

What is now DE 141 between New Castle and Newport was originally designated as part of DE 41 in the 1930s. DE 141 was designated as a surface bypass of Wilmington between New Castle and US 202 north of Wilmington in the 1950s, running concurrent with DE 41 south of Newport. DE 41 was removed from DE 141 by 1971. In the 1960s, DE 141 was proposed to be upgraded to a freeway. Construction on the freeway segments between Newport and Prices Corner and in Greenville began in the 1970s and was completed around 1980. In the 1990s, several improvements were planned for DE 141 north of Prices Corner, including grade separation at Rockland Road completed in 1997 and relocation of the northern terminus to its current location at an interchange with US 202 and DE 261 finished in 2007.